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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
YWHAH
All Species:
31.82
Human Site:
S46
Identified Species:
50
UniProt:
Q04917
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04917
NP_003396.1
246
28219
S46
N
E
D
R
N
L
L
S
V
A
Y
K
N
V
V
Chimpanzee
Pan troglodytes
XP_519163
321
36086
S120
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
Rhesus Macaque
Macaca mulatta
XP_001111955
233
26714
V40
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
Dog
Lupus familis
XP_546936
343
38553
S142
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9CQV8
246
28068
R43
H
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
Rat
Rattus norvegicus
P68511
246
28193
S46
N
E
D
R
N
L
L
S
V
A
Y
K
N
V
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505266
247
28347
S46
N
E
D
R
N
L
L
S
V
A
Y
K
N
V
V
Chicken
Gallus gallus
Q5F3W6
247
28212
S46
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
Frog
Xenopus laevis
Q6PCG0
247
28255
S46
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
Zebra Danio
Brachydanio rerio
Q6PC29
247
28216
S46
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29310
248
28209
R44
V
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
Honey Bee
Apis mellifera
XP_391841
247
28058
R43
V
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
Nematode Worm
Caenorhab. elegans
Q20655
248
28049
R43
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42644
255
28588
L46
L
S
V
E
E
R
N
L
L
S
V
A
Y
K
N
Baker's Yeast
Sacchar. cerevisiae
P34730
273
31043
L46
S
V
E
E
R
N
L
L
S
V
A
Y
K
N
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
66.9
88.6
60
N.A.
76.8
99.1
N.A.
89.4
86.2
87.8
86.2
N.A.
72.5
76.9
75.8
N.A.
Protein Similarity:
100
71.6
90.2
65
N.A.
86.9
99.5
N.A.
91.5
92.7
93.9
93.1
N.A.
85.8
87.8
86.6
N.A.
P-Site Identity:
100
93.3
6.6
93.3
N.A.
13.3
100
N.A.
100
93.3
93.3
93.3
N.A.
13.3
13.3
13.3
N.A.
P-Site Similarity:
100
100
33.3
100
N.A.
20
100
N.A.
100
100
100
100
N.A.
13.3
13.3
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
60
56.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
74.9
70.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
0
0
0
0
0
0
60
7
7
0
27
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
20
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
80
40
14
7
27
27
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
7
0
0
0
0
0
0
54
7
7
0
% K
% Leu:
7
0
27
0
0
54
60
14
7
27
27
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
54
0
0
0
80
14
7
0
27
0
0
0
54
7
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
54
7
7
0
27
0
0
7
7
0
0
0
% R
% Ser:
14
7
0
27
0
0
0
54
7
7
0
27
7
7
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
14
14
7
0
0
0
7
7
54
7
7
0
27
54
60
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
7
0
0
0
0
0
0
54
7
7
0
27
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _